Neuropsychological alterations associated with the consumption of Dextro-methyl-amphetamine in Mexican adolescents

Main Article Content

Charles Ysaacc Da Silva Rodrigues
Paula Alexandra Carvalho de Figueiredo
Paulo Pombo Marques
José Félix Gómez Calderón

Abstract

Introduction: the consumption of methamphetamine creates a chemical reaction with the dopamine segregated in the structures of the mesolimbic way, producing alterations in the behavioral emotional and cognitive processes.


Objective: the objective of this work was to identify the neuropsychological changes associated with the consumption of crystal in students of medium and high education, in an initial stage of treatment, with controlled consumption.


Method: is a comparative study, with the participation of 170 adolescents, evaluated in the neuropsychological (NEUROPSI), personality (NEO-FFI) and emotional regulation (DASS-21) categories.


Results: the evaluation of the cognitive dimensions by NEUROPSI reveal differences statistically significant between the two groups.


Discussion and conclusion: the consumption of cristal seems to produce a series of acute neuropsychological damages, as a consequence of a sintering less pure that attack to determine regions and cerebral systems. Emotional changes demonstrated to have links with the behaviours and as the same time with the neuropsychological aspect, generating changes that carry a social inadequacy by consumers.

Keywords:
methamphetamine ,  cristal ,  neuropsychology ,  emotion ,  teenagers
Published: Jul 3, 2019

Article Details

How to Cite
Rodrigues, C. Y. D. S., Carvalho de Figueiredo, P. A., Pombo Marques, P., & Gómez Calderón, J. F. (2019). Neuropsychological alterations associated with the consumption of Dextro-methyl-amphetamine in Mexican adolescents. Revista Internacional De Investigación En Adicciones, 5(1), 15–22. https://doi.org/10.28931/riiad.2019.1.03
Section
Original Articles

References

Alexander, P. D., Gicas, K. M., Willi, T. S., Kim, C. N., Boyeva, V., Procyshyn, R. M., … Barr, A. M. (2017). A comparison of psychotic symptoms in subjects with methamphetamine versus cocaine dependence. Psychopharmacology, 234(9-10), 1535-1547. doi: 10.1007/s00213-017-4551-7

Bernardi, R. E. (2015). Advances in nicotine research in Addiction Biology. Addiction Biology, 20(5), 877-889. doi: 10.1111/adb.12269

Brooks, S. J., Wiemerslage, L., Burch, K. H., Maiorana, S. A., Cocolas, E., Schiöth, H. B., … Stein, D. J. (2017). The impact of cognitive training in substance use disorder: the effect of working memory training on impulse control in methamphetamine users. Psychopharmacology, 234(12), 1911-1921. doi: 10.1007/s00213-017-4597-6

Da Silva R., C. Y. (2018). Neuropsicología del Envejecimiento. México: Manual Moderno. ISBN: 978-607-448-689-6

Gurrola Peña, G. M., Balcázar Nava, P., Bonilla Muños, M. P., Virseda Heras, J. A. (2006) Estructura factorial y consistencia interna de la escala de Depresión Ansiedad y Estrés (DASS-21) en una muestra no clínica. Psicología y Ciencia Social, 8(2), 3-7.

Lindsley, C. W., & Hopkins, C. R. (2017). Return of D4 Dopamine Receptor Antagonists in Drug Discovery. Journal of Medicinal Chemistry, 60(17), 7233-7243. doi: 10.1021/acs.jmedchem.7b00151

Lovibond, S. H., & Lovibond, P. F. (1995). Manual for the Depression Anxiety Stress Scales. 2nd. ed. Sydney: Psychology Foundation of Australia.

Lu, T., Kim, P., Greig, N., & Luo, Y. (2017). Dopaminergic Neuron-Specific Deletion of p53 Gene Attenuates Methamphetamine Neurotoxicity. Neurotoxicity Research, 32(2), 218-230. doi: 10.1007/s12640-017-9723-z

Meda-Lara, R. M., Moreno-Jiménez, B., García, L. F., Palomera Chávez, A. & Mariscal de Santiago, M. V. (2015). Validez factorial del NEO-FFI en una muestra mexicana: Propuesta de una versión reducida. Revista Mexicana de Psicología, 32(1), 57-67.

Müller, C. P., & Kornhuber, J. (2017). Biological Evidence for Paradoxical Improvement of Psychiatric Disorder Symptoms by Addictive Drugs. Trends in Pharmacological Sciences, 38(6), 501-502. doi: 10.1016/j.tips.2017.03.005

Oh, J.-H., Hwang, J.-Y., Hong, S.-I., Ma, S.-X., Seo, J.-Y., Lee, S.-Y., … Jang, C.-G. (2016). The new designer drug buphedrone produces rewarding properties via dopamine D1 receptor activation. Addiction Biology, 23(1), 69–79. doi: 10.1111/adb.12472

Ostrosky, F., Ardila, A. & Roselli, M. (2013). Neuropsi: Evaluación Neuropsicológica Breve en español. México: Manual Moderno.

Ostrosky, F., Gomez, M. E., Matute, E., Rosselli, M., Ardila, A., & Pineda D. (2019). Neuropsi: Atención y Memoria (3a. ed.). México: Manual Moderno.

Román, F., Santibáñez, P., & Vinet, E. V. (2016). Use of the Depression Anxiety Stress Scales (DASS-21) as Screening Tests in Clinical Youngsters. Acta de Investigación Psicológica, 6(1), 2325-2336.

Shokoohi, M., Karamouzian, M., Sharifi, H., Rahimi-Movaghar, A., Carrico, A. W., Hosseini Hooshyar, S., & Mirzazadeh, A. (2018). Crystal methanphetamine use and its correlates in women engaged in sex work in a developing country setting. Drug & Alcohol Dependence, 185, 260-265. doi: 10.1016/j.drugalcdep.2017.12.025

Widiger, T. A., & Costa Jr, P. T. (Eds.). (2013). Personality disorders and the five-factor model of personality. Washington, DC: American Psychological Association.

Wu, B., Lin, W., Wang, H., Abdullah, T., Wang, B., Su, Y., … Lian, Q. (2018). Glucocorticoid receptor in rat nucleus accumbens: Its roles in propofol addictions. Neuroscience Letters, 662, 115-121. doi: 10.1016/j.neulet.2017.10.011