Marijuana in Mexico: biological and social implications on legalization and regulation
Main Article Content
Abstract
Introduction: this paper identify three aspects related to debate on the legalization and regulation of marijuana in Mexico: 1) Use as medical treatment for diseases that do not have an allopath alternative, 2) do not criminalize possession and use in quantities of self-consumption and 3) for-profit industrialization and recreational consumption.
Objective: to present scientific evidence that opposes to possibility of legalizing the use of marijuana in “business” or recreational sector.
Method: bibliographic searches were made in databases of scientific journals.
Results: scientific evidence indicates that marijuana has biological, psychological and social effects.
Discussion and conclusions: the possibility of providing to Mexican population with recreational marijuana represents a risk to public health. In Mexico we do not have sanitary and professional conditions to counteract drug dependence.
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
References
ABC (2016, 7 de septiembre). El primer ministro de Nueva Zelanda dice que necesitan inmigrantes porque los neozelandeses son vagos y toman drogas. Recuperado de http://www.abc.es/internacional/abci-primer-ministro-nueva-zelanda-dice-necesitan-inmigrantes-porque-neozelandeses-vagos-y-toman-drogas-201609061232_noticia.html
Alameda J., Paino, S., & Mogedas, A. (2012). Toma de decisiones en consumidores de cannabis. Adicciones, 24(2), 161-172.
Aldington, S., Harwood, M., Cox, B., Weatherall, M., Beckert, L., Hansell, A., … Beasley, R. (2008). Cannabis use and risk of lung cancer: a case-control study. European Respiratory Journal, 31(2), 280-286. doi: 10.1183/09031936.00065707
Ansell, E., Laws, H., Roche, M., & Sinha, R. (2015). Effects of marijuana use on impulsivity and hostility in daily life. Drug and Alcohol Dependence, 148, 136-142. doi: 10.1016/j.drugalcdep.2014.12.029
Arseneault, L., Cannon, M., Poulton, R., Murray, R., Caspi, A., & Moffitt, T. (2002). Cannabis use in adolescence and risk for adult psychosis: longitudinal prospective study. British Medical Journal, 325(7374), 1212-1213.
Arseneault, L., Cannon, M., Witton, J., & Murray, R. (2004). Causal association between cannabis and psychosis: examination of the evidence. The British Journal of Psychiatry, 184(2), 110-117.
Asbridge, M., Hayden, J., & Cartwringht, J. (2012). Acute cannabis consumption and motor vehicle collision risk: systematic review of observational studies and meta-analysis. British Medical Journal, 344(e536), 1-9. doi: 10.1 136/bmj.e536
Balleine, B. W. (2005). Neural bases of food-seeking: affect, arousal and reward in corticostriatolimbic circuits. Physiology & Behavior, 86(5), 717-730. doi: 10.1016/j.physbeh.2005.08.061
Battisti, R. A., Roodenrys, S., Johnstone, S. J., Respondek, C., Hermens, D. F., & Solowij, N. (2010). Chronic use of cannabis and poor neural efficiency in verbal memory ability. Psychopharmacology, 209(4), 319-330. doi: 10.1007/s00213-010-1800-4
Beaulieu, P., Boulanger, A., Desroches, J., & Clark, A. J. (2016). Medical cannabis: considerations for the anesthesiologist and pain physician. Canadian Journal of Anesthesia/Journal Canadien d’Anesthésie, 63(5), 608-624. doi: 10.1007/s12630-016-0598-x
Belrness, D., & Porath-Waller, A. (2015). Clearing the smoke on cannabis. Cannabis use and driving–an update. Canada: Canadian Centre on Substance Abuse. Recuperado de http://www.cclt.ca/Resource%20Library/CCSA-Cannabis-Use-and-Driving-Report-2015-en.pdf
Berridge, K., & Robinson, T. (1998). What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? Brain Research Reviews, 28(3), 309-369. doi: 10.1016/s0165-0173(98)00019-8
Beverido, P. (2010). Consumo de mariguana y sus efectos en la salud mental y las habilidades cognitivas necesarias para el aprendizaje. Revista Médica Universidad Veracruzana. 10(2), 49-53.
Birdsall, S. M., Birdsall, T. C., & Tims, L. A. (2016). The use of medical marijuana in cancer. Current Oncology Reports, 18(7), 1-9. doi: 10.1007/s11912-016-0530-0
Bolla, K. I., Brown, K., Eldreth, D., Tate, K., & Cadet, J. (2002). Dose-related neurocognitive effects of marijuana use. Neurology, 59(9), 1337-1343. doi: 10.1212/01.wnl.0000031422.66442.49
Borges, G., Benjet, C., Orozco, R., Medina-Mora, M. E., & Menéndez, D. (2017). Alcohol, cannabis and other drugs and subsequent suicide ideation and attempt among young Mexicans. Journal of Psychiatric Research, 91, 74-82. doi: 10.1016/j.jpsychires.2017.02.025
Brady, J., & Li, G. (2014). Trends in alcohol and other drugs detected in fatally injured drivers in the United States, 1999-2010. American Journal of Epidemiology, 179(6), 692-699. doi: 10.1093/aje/kwt327
Brook, J., Lee, J., Finch, S., Seltzer, N., & Brook, D. (2013). Adult work commitment, financial stability, and social environment as related to trajectories of marijuana use beginning in adolescence. Substance Abuse, 34(3), 298-305. doi: 10.1080/08897077.2013.775092
Budney, A. J., & Hughes, J. R. (2006). The cannabis withdrawal syndrome. Current Opinion Psychiatry, 19(3), 233-238. doi: 10.1097/01.yco.0000218592.00689.e5
Bunge, M. A. (1979). Treatise on basic philosophy. Ontology II: a world of systems. Londres: D. Reidel Publishing Company.
Bush, V. P. (2010). Proyecciones de la población de México 2005-2050. México: CONAPO.
Citri, A., & Malenka, R. C. (2008). Synaptic plasticity: multiple forms, functions and mechanisms. Neuropsychopharmacology, 33(1), 18-41. doi: 10.1038/sj.npp.1301559
Cota, D., Tschöp, M. H., Horvath, T. L., & Levine, A. S. (2006). Cannabinoids, opioids and eating behavior: The molecular face of hedonism? Brain Research Reviews, 51(1), 85-107. doi: 10.1016/j.brainresrev.2005.10.004
Cotter, J. (2009). Efficacy of crude marijuana and synthetic Delta-9-Tetrahydrocannabinol as treatment for chemotherapy-induced nausea and vomiting: a systematic literature review. Oncology Nursing Forum, 36(3), 345-352. doi: 10.1188/09.onf.345-352
Crancer, A., & Crancer, A. (2010). The involvement of marijuana in California fatal motor vehicle crashes 1998-2008 (working paper). California: Institute for Behavior and Health, Inc. Recuperado de http://truecompassion.org/PDFS/Drugged%20Driving/CA%20MJ%20Study%20The%20involvement%20of%20mj%20in%20fatal%20car%20accidents.pdf
Crane, N. A., Schuster, R. M., Fusar-Poli, P., & Gonzalez, R. (2012). Effects of cannabis on neurocognitive functioning: recent advances, neurodevelopmental influences and sex differences. Neuropsycholgy Review, 23(2), 117-137. doi: 10.1007/s11065-012-9222-1
Deadwyler, S. A., & Hampson, R. E. (2008). Endocannabinoids modulate encoding of sequential memory in the rat hippocampus. Psychopharmacology, 198(4), 577-586. doi: 10.1007/s00213-007-1055-x
Degenhardt, L., & Hall, W. (2002). Cannabis and psychosis. Current Psychiatry Reports, 4(3), 191-196. doi: 10.1007/s11920-002-0026-5
Degenhardt, L., & Hall, W. (2006). Is cannabis use a contributory cause of psychosis? Canadian Journal of Psychiatry, 51(9), 556-565. doi: 10.1177/070674370605100903
Degenhardt, L., Coffey, C., Romaniuk, H., Swift, W., Carlin, J., Hall, W., … Patton, G. (2013). The persistence of the association between adolescent cannabis use and common mental disorders into young adulthood. Addiction,108(1), 124-133. doi: 10.1111/j.1360-0443.2012.04015.x
Degenhardt, L., Hall, W., & Lynskey, M. (2003). Exploring the association between cannabis use and depression. Addiction, 98(11), 1493-1504. doi: 10.1046/j.1360-0443.2003.00437.x
D’Amico, E. J., Miles, J. N. V., & Tucker, J. S. (2015). Gateway to curiosity: medical marijuana ads and intention and use during middle school. Psychology of Addictive Behaviors, 29(3), 613-619. doi: 10.1037/adb0000094
Elkashef, A., Vocci, F., Huestis, M., Haney, M., Budney, A., Gruber, A., & el-Guebaly, N. (2008). Marijuana neurobiology and treatment. Substance Abuse, 29(3), 17-29. doi: 10.1080/08897070802218166
Elliott, L. (2016). Criminal networks and black markets in transnational environmental crime, in toine spapens. Rob White, & Wim Huisman (ed.). Environmental crime in transnational context: global issues in green enforcement and criminology (pp. 233-249). Abingdon, Oxon: Routledge Taylor & Francis Group.
Fergusson, D. M., Boden, J. M., & Horwood, L. J. (2006). Cannabis use and other illicit drug use: testing the cannabis gateway hypothesis. Addiction, 101(4), 556–569. doi: 10.1111/j.1360-0443.2005.01322.x
Fergusson, D., & Boden, J. (2008). Cannabis use and later life outcomes. Addiction, 103(6), 969-976. doi: 10.1111/j.1360-0443.2008.02221.x
Filbey, F., Aslan, S., Calhoun, V., Spence, J., Damaraju, E., Caprihan, A., … Segall, J. (2014). Long-term effects of marijuana use on the brain. Proceedings of the National Academy of Sciences, 111(47), 16913-16918. Recuperado de www.pnas.org/cgi/doi/10.1073/pnas.1415297111
Fogarty, A., Rawstorne, P., Prestage, G., Crawford, J., Grierson, J., & Kippax, S. (2007). Marijuana as therapy for people living with HIV/AIDS: social and health aspects. AIDS Care, 19(2), 295-301. doi: 10.1080/09540120600841930
Freisthler, B., & Gruenewald, P. (2014). Examining the relationship between the physical availability of medical marijuana and marijuana use across fifty California cities. Drug and Alcohol Dependence, 143, 244-250. doi: 10.1016/j.drugalcdep.2014.07.036
Freund, T. F., Katona, I., & Piomelli, D. (2003). Role of endogenous cannabinoids in synaptic signaling. Physiological Reviews, 83(3), 1017-1066. doi: 10.1152/physrev.00004.2003
Fried, P., Watkinson, B., James, D., & Gray, R. (2002). Current and former marijuana use: preliminary findings of a longitudinal study of effects on IQ in young adults. Canadian Medical Association Journal, 166(7), 887-891.
Garfield, J. B. B., Lubman, D. I., & Yücel, M. (2013). Anhedonia in substance use disorders: a systematic review of its nature, course and clinical correlates. Australian & New Zealand Journal of Psychiatry, 48(1), 36-51. doi: 10.1177/0004867413508455
Garry, A., Rigourd, V., Amirouche, A., Fauroux, V., Aubry, S., & Serreau, R. (2009). Cannabis and breastfeeding. Journal of Toxicology, 2009, 1-5. doi: 10.1155/2009/596149
Gerdeman, G. L., & Lovinger, D. M. (2003). Emerging roles for endocannabinoids in long-term synaptic plasticity. British Journal of Pharmacology, 140(5), 781-789. doi: 10.1038/sj.bjp.0705466
Gilman, J. M., Kuster, J. K., Lee, S., Lee, M. J., Kim, B. W., Makris, N., … Breiter, H. C. (2014). Cannabis use is quantitatively associated with nucleus accumbes and amygdala abnormalities in young adult recreational users. The Journal of Neuroscience, 34(16), 5529-5538. doi: 10.1523/jneurosci.4745-13.2014
Hall, W. (2009). The adverse effects of cannabis use. What are they and what are their implications for policy? International Journal of Drug Policy, 20(6), 458-466. doi: 10.1016/j.drugpo.2009.02.013
Hall, W., & Degenhardt, L. (2009). Adverse health effects of non-medical cannabis use. The Lancet, 374(9698), 1383-1391. doi: 10.1016/s0140-6736(09)61037-0
Hall, W., Degenhardt, L., & Teesson, M. (2004). Cannabis use and psychotic disorders: an update. Drug and Alcohol Review, 23(4), 433-443. doi: 10.1080/09595230412331324554
Hanson, K. L., Winward, J. L., Schweinsburg, A. D., Medina, K. L., Brown, S. A., & Tapert, S. (2010). Longitudinal study of cognition among adolescent marijuana users over three weeks of abstinence. Addictive Behaviours, 35(11), 970-976. doi: 10.1016/j.addbeh.2010.06.012
Hart, C. L., Ward, A. S., Haney, M., Comer, S. D., Foltin, R. W., & Fischman, M. W. (2002). Comparison of smoked marijuana and oral Δ9-tetrahydrocannabinol in humans. Psychopharmacology, 164(4), 407-415. doi: 10.1007/s00213-002-1231-y
Hebert-Chatelain, E., Desprez, T., Serrat, R., Bellocchio, L., Soria-Gomez, E., Busquets-Garcia, A., ... Marsicano, G. (2016). A cannabinoid link between mitochondria and memory. Nature, 539(7630), 555-559. doi: 10.1038/nature20127
Hurd, Y. L., Michaelides, M., Miller, M. L., & Jutras-Aswad, D. (2014). Trajectory of adolescent cannabis use on addiction vulnerability. Neuropharmacology, 76, 416-424. doi: 10.1016/j.neuropharm.2013.07.028
Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Instituto Nacional de Salud Pública, & Secretaría de Salud. (2012). Encuesta Nacional de Adicciones 2011: Reporte de Drogas. Villatoro-Velázquez, J. A., Medina-Mora, M. E., Fleiz-Bautista, C., Téllez-Rojo, M. M., Mendoza-Alvarado, L. R., Romero-Martínez, M.,… Guisa-Cruz, V. México: INPRFM.
Iversen, L. (2003). Cannabis and the brain. Brain, 126(6), 1252-1270. doi: 10.1093/brain/awg143
Jain, R., & Singh, Y. (2008). Neurobiology of cannabis addiction. Indian Journal of Physiological Pharmacology, 52(3), 217-232.
Ji, T. H., Grossmann, M., & Ji, I. (1998). G protein-coupled receptors. Diversity of receptor-ligand interactions. Journal of Biological Chemistry, 273(28), 17299-17302. doi: 10.1074/jbc.273.28.17299
Jouanjus, E., Lapeyre-Mestre, M., & Micallef, J. (2014). Cannabis use: signal of increasing risk of serious cardiovascular disorders. Journal of the American Hearth Association, 32(2) 1-7 doi: 10.1161/jaha.113.000638
Justinova, Z., Goldberg, S. R., Heishman, S. J., & Tanda, G. (2005). Self administration of cannabinoids by experimental animals and human marijuana smokers. Pharmacology Biochemistry and Behavior, 81(2), 285-299. doi: 10.1016/j.pbb.2005.01.026
Katona, I., & Freund, T. F. (2008). Endocannabinoid signaling as a synaptic circuit breaker in neurological disease. Nature Medicine, 14(9), 923-930. doi: 10.1038/nm.f.1869
Kowal, M. A., Hazekamp, A., Colzato, L. S., van Steenbergen, H., van der Wee, N. J. A., Durieux, J., … Hommel, B. (2015). Cannabis and creativity: highly potent cannabis impairs divergent thinking in regular cannabis users. Psychopharmacology, 232(6), 1123-1134. doi: 10.1007/s00213-014-3749-1
Kruk-Slomka, M., & Biala, G. (2016). CB1 receptors in the formation of the different phases of memory-related processes in the inhibitory avoidance test in mice. Behavioral Brain Research, 301, 84-95. doi: 10.1016/j.bbr.2015.12.023
Kulis, S., Marsiglia, F. F., Elek, E., Dustman, P. A., Wagstaff, D. A., & Hecht, M. L. (2005). Mexican/Mexican American adolescents and Keepin’ it REAL: an evidence-based substance use prevention program. Children and Schools, 27(3), 133-145. doi.org/10.1093/cs/27.3.133
Large, M., Sharma, S., Compton, M., Slade, T., & Nielssen, O. (2011). Cannabis use and earlier onset of psychosis: a systematic meta-analysis. Archives of General Psychiatry, 68(6), 555-561. doi: 10.1001/archgenpsychiatry.2011.5
Laumon, B., Gadegbeku, B., Martin, J. L., & Biecheler, M. B. (2005). Cannabis intoxication and fatal road crashes in France: population based case-study. British Medical Journal, 331(7529), 1-6 doi: 10.1136/bmj.38648.617986.1F
Leleu-Chavain, N., Desreumaux, P., Chavatte, P., & Millet, R. (2014). Therapeutical potential of CB2 receptors in immune-related diseases. Current Molecular Pharmacology, 6(3), 183-203. doi: 10.2174/1874467207666140219122337
Lev-Ran, S., Roerecke, M., Le Foll, B., George, T. P., McKenzie, K., & Rehm, J. (2013). The association between cannabis use and depression: a systematic review and meta-analysis of longitudinal studies. Psychological Medicine, 44(04), 797-810. doi: 10.1017/s0033291713001438
Ley General de Salud. (2009). Decreto por el que se reforman, adicionan y derogan diversas disposiciones de la Ley General de Salud, del Código Penal Federal y del Código Federal de Procedimientos Penales. México. Recuperado de http://dof.gob.mx/nota_detalle_popup.php?codigo=5106093.
López-Quintero, C., Pérez de los Cobos, J., Hasin, D., Okuda, M., Wang, S., Grant, B., … Blanco, C. (2011). Probability and predictors of transition from first use to dependence on nicotine, alcohol, cannabis, and cocaine: results of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). Drug and Alcohol Dependence, 115(1-2), 120-130. doi: 10.1016/j.drugalcdep.2010.11.004
Lorenzetti, V., Solowij, N., Whittle, S., Fornito, A., Lubman, D. I., Pantelis, C., & Yücel, M. (2015). Gross morphological brain changes with chronic, heavy cannabis use. The British Journal of Psychiatry, 206(1), 77-78. doi: 10.1192/bjp.bp.114.151407
Lubman, D. I., Cheetham, A., & Yücel, M. (2015). Cannabis and adolescent brain development. Pharmacology & Therapeutics, 148, 1-16. doi: 10.1016/j.pharmthera.2014.11.009
Lupica, C. R., Riegel, A. C., & Hoffman, A. F. (2004). Marijuana and cannabinoid regulation of brain reward circuits. British Journal of Pharmacology, 143(2), 227-234. doi: 10.1038/sj.bjp.0705931
Lynskey, M., & Hall, W. (2000). The effects of adolescent cannabis use on educational attainment: a review. Addiction, 95(11), 1621-1630. doi: 10.1046/j.1360-0443.2000.951116213.x
MacCoun, R. J. (2011). What can we learn from the Dutch cannabis coffeeshop system? Addiction, 106(11), 1899-1910. doi: 10.1111/j.1360-0443.2011.03572.x
Maldonado, R., Berrendero, F., Ozaita, A., & Robledo, P. (2011). Neurochemical basis of cannabis addiction. Neuroscience, 181, 1-17. doi: 10.1016/j.neuroscience.2011.02.035
Malinow, R., Mainen, Z. F., & Hayashi, Y. (2000). LTP mechanisms: from silence to four-lane traffic. Current Opinion in Neurobiology, 10(3), 352-357. doi: 10.1016/s0959-4388(00)00099-4
Marín-Navarrete, R., Medina-Mora, M. E., & Tena-Suck, A. (2016). Addiction care in Mexico: a challenge for non-specialized health professionals. Salud Mental, 39(5), 241-242. doi: 10.17711/sm.0185-3325.2016.027
Marsicano, G., & Lafenêtre, P. (2009). Roles of the endocannabinoid system in learning and memory. En Behavioral Neurobiology of the Endocannabinoid System (pp. 201-230). Berlín: Springer Berlin Heidelberg.
Matsuda, L. A., Lolait, S. J., Brownstein, M. J., Young, A. C., & Bonner, T. I. (1990). Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature, 346(6284), 561-564. doi: 10.1038/346561a0
Maykut, M. O. (1985). Health consequences of acute and chronic marijuana users. Progress in Neuro-Psychomacology and Biological Psychiatry, 9(3), 209-238. doi: 10.1016/0278-5846(85)90085-5
Meier, M. H., Caspi, A., Ambler, A., Harrington, H., Houts, R., Keefe, R. S. E., … Moffitt, T. E. (2012). Persistent cannabis users show neuropsychological decline from childhood to midlife. Proceedings of the National Academy of Sciences. 109(40), E2657-E2664. doi: 10.1073/pnas.1206820109
Mena, I., Dörr, A., Viani, S., Neubauer, S., Gorostegui, M., Dörr, P., & Ullca, D. (2013). Efectos del consumo de la marihuana en escolares sobre funciones cerebrales demostrados mediante pruebas neuropsicológicas e imágenes de neuro-SPECT. Salud Mental, 36(5), 367-374. doi: 10.17711/sm.0185-3325.2013.045
Miller, N., & Gold, M. (1989). The diagnosis of marijuana (cannabis) dependence. Journal of Substance Abuse Treatment, 6(3), 183-192. doi: 10.1016/0740-5472(89)90005-6
Moore, T. H., Zammit, S., Lingford-Hughes, A., Barnes, T. R., Jones, P. B., Burke, M., & Lewis, G. (2007). Cannabis use and risk of psychotic or affective mental health outcomes: a systematic review. The Lancet, 370(9584), 319–328. doi: 10.1016/s0140-6736(07)61162-3
Munro, S., Thomas, K. L., & Abu-Shaar, M. (1993). Molecular characterization of a peripheral receptor for cannabinoids. Nature, 365(6441), 61–65. doi: 10.1038/365061a0
Nielsen, S., Germanos, R., Weier, M., Pollard, J., Degenhardt, L., Hall, W., ... Farrell, M. (2018). The use of cannabis and cannabinoids in treating symptoms of multiple sclerosis: a systematic review of reviews. Current Neurology and Neuroscience Reports, 18(2), 1-12. doi: 10.1007/s11910-018-0814-x
Oficina de las Naciones Unidas contra la Droga y el Delito. (2003). Global illicit drug trends. Vienna, Austria: United Nations International Drug Control Programme Research Section.
Owen, K. P., Sutter, M. E., & Albertson, T. E. (2013). Marijuana: respiratory tract effects. Clinical Reviews in Allergy and Immunology, 46(1), 65-81. doi: 10.1007/s12016-013-8374-y
Patton, G., Coffey, C., Carlin, J., Degenhardt, L., Lynskey, M., & Hall, W. (2002). Cannabis use and mental health in young people: cohort study. British Medical Journal, 325(7374), 1195-1198. doi: 10.1136/bmj.325.7374.1195
Pertwee, R. G. (1997). Pharmacology of cannabinoid CB1 and CB2 receptors. Pharmacology & Therapeutics, 74(2), 129-180. doi: 10.1016/s0163-7258(97)82001-3
Pertwee, R. G. (2006). The pharmacology of cannabinoid receptors and their ligands: an overview. International Journal of Obesity, 30(S1), s13-s18. doi: 10.1038/sj.ijo.0803272
Piomelli, D. (2003). The molecular logic of endocannabinoid signalling. Nature Reviews, Neuroscience, 4(11), 873-884. doi: 10.1038/nrn1247
Pope, H. G., Gruber, A. J., Hudson, J. I., Huestis, M. A., & Yurgelum-Todd, D. (2001). Neuropsychological performance in long-term cannabis users. Archives of General Psychiatry, 58(10), 909-915. doi: 10.1001/archpsyc.58.10.909
Reece, A. S. (2009). Chronic toxicology of cannabis. Clinical Toxicology, 47(6), 517-524. doi: 10.108/15563650903074507
Robinson, L., McKillop-Smith, S., Ross, N. L., Pertwee, R. G., Hampson, R. E., Platt, B., … Riedel, G. (2007). Hippocampal endocannabinoids inhibit spatial learning and limit spatial memory in rats. Psychopharmacology, 198(4), 551-563. doi: 10.1007/s00213-007-1012-8
Salomonsen-Sautel, S., Min, S., Sakai, J., Thurstone, C. & Hopfer, C. (2014). Trends in fatal motor vehicle crashes before and after marijuana commercialization in Colorado. Drug Alcohol Dependence, 140, 137-144. doi: 10.1016/j.drugalcdep.2014.04.008
Salomonsen-Sautel, S., Sakai, J., Thurstone, C., Corley, R., & Hopfer, C. (2012). Medical marijuana use among adolescents in substance abuse treatment. Journal of the American Academy of Child & Adolescent Psychiatry, 51(7), 694-702. doi: 10.1016/j.jaac.2012.04.004
Secretaría de Gobernación. (2016). Relatoría del debate nacional sobre el uso de la mariguana. México: Segob, SSa. Recuperado de http://framework-gb.cdn.gob.mx/data/420/RELATORIA_DEBATE_NAL_USO_MARIGUANA_PRELIMINAR.pdf.
Secretaría de Salud. (2017). Decreto por el que se reforman y adicionan diversas disposiciones de la Ley General de Salud y del Código Penal Federal. Reforma 107: Ley General de Salud. Diario Oficial de la Federación. (DOF 19-06-2017). Recuperado de www.diputados.gob.mx/LeyesBiblio/ref/lgs/LGS_ref107_19jun17.doc
Semple, D., McIntosh, A., & Lawrie, S. (2005). Cannabis as a risk factor for psychosis: systematic review. Journal of Psychopharmacology, 19(2), 187-194. doi: 10.1177/0269881105049040
Sigfúsdóttir, I. D., Thorlindsson, T., Kristjánsson, A. L., Roe, K. M., & Allegrante, J. P. (2008). Substance use prevention for adolescents: the Icelandic model. Health Promotion International, 24(1), 16-25. doi: 10.1093/heapro/dan038
Simons, J., Clarke, J., Simons, R., & Spelman, P. (2016). Marijuana consequences in a motivational context: goal congruence reduces likelihood of taking steps toward change. Addictive Behaviors, 52, 83-90. doi: 10.1016/j.addbeh.2015.08.010
Sullivan, J. M. (2000). Cellular and molecular mechanisms underlying learning and memory impairments produced by cannabinoids. Learning & Memory, 7(3), 132-139. doi: 10.1101/lm.7.3.132
Szabo, B., Siemes, S., & Wallmichrath, I. (2002). Short communication. Inhibition of GABAergic neurotransmission in the ventral tegmental area by cannabinoids. European Journal of Neuroscience, 15(12), 2057-2061. doi: 10.1046/j.1460-9568.2002.02041.x
Tapert, S., Schweinsburg, A., & Brown, S. (2008). The influence of marijuana use on neurocognitive functioning in adolescents. Current Drug Abuse Reviews, 1(1), 99-111. doi: 10.2174/1874473710801010099
Tebano, M. T., Martire, A., & Popoli, P. (2012). Adenosine A 2A–cannabinoid CB1 receptor interaction: an integrative mechanism in striatal glutamatergic neurotransmission. Brain Research, 1476, 108-118. doi: 10.1016/j.brainres.2012.04.051
Van Os, J., Bak, M., Hanssen, M., Bijl, R., de Graaf, R., & Verdoux, H. (2002). Cannabis use and psychosis: a longitudinal population-based study. American Journal of Epidemiology, 156(4), 319-327. doi: 10.1093/aje/kwf043
Velasco, R. (1997). El problema de la farmacodependencia. En Ramón de la Fuente (Coord.). La patología mental y su terapéutica II. México: Fondo de Cultura Económica.
Velázquez, J. A., Icaza, M. E., Sánchez, R., Ito, D. A., … Gamiño, M. N. (2016). El consumo de drogas en estudiantes de México: tendencias y magnitud del problema. Salud Mental, 39(4), 193–203. doi: 10.17711/sm.0185-3325.2016.023
Vélez, A., Borja, K., & Ostrosky-Solís, F. (2010). Efectos del consumo de marihuana sobre la toma de decisión. Revista Mexicana de Psicología, 27(2), 309-315.
Velleman, R. D., Templeton, L. J., & Copello, A. G. (2005). The role of the family in preventing and intervening with substance use and misuse: a comprehensive review of family interventions, with a focus on young people. Drug and Alcohol Review, 24(2), 93-109. doi: 10.1080/09595230500167478
Verdejo-García, A. (2011). Efectos neuropsicológicos del consumo de cannabis. Trastornos adictivos, 13(03), 97–101. doi: 10.1016/s1575-0973(11)70021-6
Villanueva, C. (2010). Los pros y los contras del uso de la mariguana. Cuicuilco, 17(49), 13-30.
Volkow, N. D., Baler, R. D., Compton, W. M., & Weiss, S. R. B. (2014). Adverse health effects of marijuana use. New England Journal of Medicine, 370(23), 2219-2227. doi: 10.1056/nejmra1402309
Wagner, F., & Anthony, J. (2002a). Into the world of illegal drug use: exposure opportunity and other mechanisms linking the use of alcohol, tobacco, marijuana, and cocaine. American Journal of Epidemiology, 155(10), 918-925. doi: 10.1093/aje/155.10.918
Wagner, F., & Anthony, J. (2002b). From first drug use to drug dependence: developmental periods of risk for dependence upon marijuana, cocaine, and alcohol. Neuropsychopharmacology, 26(4), 479-488. doi: 10.1016/s0893-133x(01)00367-0
Warner, T., Roussos-Ross, D., & Behnke, M. (2014). It´s not your mother´s marijuana: effects on maternal-fetal health and developing child. Clinics of Perinatology, 41, 877-894. doi: 10.1016/j.clp.2014.08.009
Whiting, P. F., Wolff, R. F., Deshpande, S., Di Nisio, M., Duffy, S., Hernandez, A. V., … Kleijnen, J. (2015). Cannabinoids for medical use: a systematic review and meta-analysis. Journal of the American Medical Association (JAMA), 313(24), 2456-2473. doi: 10.1001/jama.2015.6358
Yamamoto, I., Watanabe, K., Matsunaga, T., Kimura ,T., Funahashi, T., & Yoshimura, H. (2003). Pharmacology and toxicology of major constituents of marijuana—on the metabolic activation of cannabinoids and its mechanism. Journal of Toxicology: Toxin Reviews, 22(4), 577-589. doi: 10.1081/txr-120026915
Yeomans, M. R., & Gray, R. W. (2002). Opioid peptides and the control of human ingestive behaviour. Neuroscience and Biobehavioral Reviews, 26(6), 713-128. doi: 10.1016/s0149-7634(02)00041-6
Zalesky, A., Solowij, N., Yücel, M., Lubman, D., Takagi, M., Harding, I., … Seal, M. (2012). Effect of long-term cannabis use on axonal fibre connectivity. Brain, 135(7), 2245–2255. doi: 10.1093/brain/aws136
Zammit, S. Moore, T., Lingford-Hughes, A., Barnes, T., Jones, P., Burke, M., … Lewis, G. (2008). Effects of cannabis use on outcomes of psychotic disorders: Systematic review. British Journal of Psychiatry, 193(5) 357-363. doi: 10.1192/bjp.bp.107.046375